This study is a case control series of patients assessing the performance of digital breast tomosynthesis + simulated mammogram with tomosynthesis + FFDM. The series of 123 patients included both normals (defined as 1yr followup normal mammo) as well as biopsy/surgery proven benign and malignant lesions. Lesions included both asymmetries and microcalcifications.
Overall the study demonstrates similar performance of the simulated mammogram and FFDM when both are combined with tomosynthesis. The study did not report the dose of the two techniques in the study used. This study is further limited in that it is a population of convenience as opposed to a true screening population, and future work with true prospective screening is required for this technology. Another limitation of this study (and most assessments of the simulated 2D mammogram) is the lack of comparison between FFDM alone and Tomo+simulated mammo in a non-inferiority analysis for sensitivity and assessment of specificity, and a true comparison of the total dose from the two techniques.
PICO Analysis:
Population: Case-Control series of 123 patients
Intervention: Tomosynthesis + Simulated 2D Mammogram
Comparison: Tomosynthesis + FFDM
Outcome: ROC
Reference:
Pubmed Full Text
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