This meta-analysis of the current literature found 7 studies meeting their inclusion criteria for assessment of multiparametric MRI for prostate cancer (defined as using both T2-weighted imaging and functional MR techniques DWI and DCEMRI). All studies had to include comparison with either biopsy or surgical histopathology. Studies were assessed for quality using QUADAS-2.
Overall the meta-analysis of pooled data demonstrated a specificity of 0.88 and sensitivity of 0.74 for prostate cancer detection, with variable NPV ranging from 0.65 to 0.94.
The meta-analysis is methodologically sound, but does have a limited pool of only 7 studies to assess. This provides a good overview of the current literature and provides further evidence of the role of MRI in assessment of patients with suspected or diagnosed prostate cancer.
PICO Analysis:
Population: Patients with suspected prostate cancer.
Intervention: Multiparametric prostate MRI.
Comparison: Surgical or Biopsy histopathology.
Outcome: Sensitivity & Specificity.
Reference:
Pubmed Full Text
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